OUR PLATFORM

Introducing a gene therapy platform which rebalances
the body’s response

Our breakthrough therapy, XT-150, addresses pathologic inflammation. Numerous diseases involve inflammation and impairments to IL-10 signaling as part of their disease pathology. Xalud is currently evaluating the effects of treatment with XT- 150 across multiple indications in preclinical and clinical models.

XT-150 Platform Indications

OSTEOARTHRITIS (LEAD INDICATION)​​

Osteoarthritis (OA) is a chronic, progressive joint disease that affects over 30 million people in the United States and over 300 million worldwide. In OA, articular cartilage breaks down, resulting in pain, loss of joint flexibility, bone degeneration, and inflammation. Xalud has completed three successful phase 1 studies (NCT03282149, NCT03477487, and NCT03769662) and initiated an international, double-blind, placebo-controlled phase 2 study (NCT04124042) evaluating the safety and efficacy of XT-150 in adult participants with moderate-to-severe pain due to OA of the knee.

NEUROPATHIC PAIN

 

The estimated prevalence of probable neuropathic pain in the US is approximately 10%. This debilitating disorder results from injury or damage to nerves in the body when an ensuing cycle of injury/damage is established and reinforced, resulting in persistent, pathological pain. Xalud has initiated a double-blind, placebo-controlled, phase 1 study (NCT04466410) in adults with chronic neuropathic radicular pain.

FACET JOINT SYNDROME

Facet joint syndrome is a painful, progressive inflammatory condition affecting the vertebral joints in the back and neck. Damage to these synovial joints due to aging or trauma may result in chronic neck or back pain. The prevalence of lumbosacral facet joint syndrome is is quite common with estimates from X to Y; lumbar facet joints are likely a source of chronic low back pain for 4 million to 13 million people in the United States.

DEGENERATIVE DISC DISEASE

Approximately 15 million people in the United States are diagnosed with a symptomatic degenerative spine condition each year. Degenerative disc disease is often an age-related condition that occurs when vertebral discs become damaged and lose structural integrity.

 

RADICULITIS

Pain caused by radiculitis, compression of a nerve root as it exits the spinal column, affects approximately 12 million adults in the US.
 

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