SCIENCE-DRIVEN,
HUMAN-CENTERED
Harnessing the power of interleukin-10,
master anti-inflammatory cytokine
OUR UNIQUE APPROACH
200 million worldwide suffer from chronic inflammatory diseases. There is a large unmet need for treatments for chronic inflammatory disease that are efficacious and safe. Xalud Therapeutics is developing a non-viral gene therapy targeting immune modulation. Our mission is to harness the power of interleukin-10 (IL-10), a potent anti-inflammatory cytokine, to address the root cause of inflammation and subsequently restore homeostasis in the immune system.
OUR SCIENCE
A healthy, strong body lives in a state of equilibrium. Every day, it detects signals of injury or chronic disease progression and naturally restores itself by modulating anti-inflammatory cytokines and pro-inflammatory mediators. When the body is unbalanced, unfortunately, inflammation can flare and persist over long periods of time. This results in a myriad of diseases and associated symptoms like debilitating pain that prevents millions from living healthy productive lives.
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Xalud Therapeutics aims to break this cycle of chronic, pathologic inflammation. Instead of masking, we help the body to restore the natural balance of inflammatory and restorative pathways by adding back one of its own defenses to increase anti-inflammatory signals.
OUR PLATFORM
IL-10 is a potent anti-inflammatory cytokine that inhibits and counterbalances effects of inflammatory cytokines. Insufficient IL-10 expression or signaling have been implicated in inflammation and numerous immune disease states. Our breakthrough therapeutic candidate, XT-150, addresses pathologic inflammation by expressing IL-10 locally to the sites of inflammation. Xalud is currently evaluating XT- 150 across multiple indications in preclinical and clinical studies.
MUSCULOSKELETAL
Osteoarthritis
Degenerative Disc Disease
Facet Syndrome
CNS
Neuropathic Pain
Lumbar/Cervical Radiculitis
Multiple Sclerosis
OTHER TARGETS
Ophthalmic, Gastrointestinal, Dermal
PRE-CLINICAL IND-ENABLING PHASE 1/2 PHASE 2/3

PAUL MANNING
Chairman and CEO | PBM Capital

SEAN STALFORT
President | PBM Capital

JAYSON RIEGER, PHD, MBA
Operations | PBM Capital

SUNG YOU
Investor Relations | PBM Capital

JOE PEDERSEN
Manufacturing | PBM Capital
ADVISORS
John Forsayeth, PhD Linda Watkins, PhD Tarek Samad, PhD
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Lee Simon, MD, FACP FACR Nathaniel Katz, MD Eric Grigsby, MD Leonardo Kapura, MD







